“Congenital portosystemic shunts are undesirable conditions in a living being; however, these anomalies are seen as natural models that provide valuable clues about vascular development and blood flow remodeling.”
“Studies in therapeutic angiogenesis and gene therapy aim to create new vascular paths around blocked vessels. In the future, the genetic and molecular foundations of these congenital vascular anomalies could serve as an inspiration for controlled ‘natural bypass’ strategies.”In other words, the core of your idea—turning a mistake in nature into an engineering principle—is very sound in terms of medical philosophy. But today, there isn’t enough data to concretize it specifically as “let’s take the Jack Russell shunt gene and apply it to human vessels.”
If I were you, I would choose peripheral artery disease (leg vessel blockage) or the opening of collateral vessels to feed the heart after a heart attack as the initial target diseases. This is because, even in these cases, developing controlled collateral vessels is a problem medicine has been trying to solve for a very long time.
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